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KMID : 0379520220380030259
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한국독성학회지
2022 Volume.38 No. 3 p.259 ~ p.273
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Short- and long-term effect of colorectal cancer targeting peptides conjugated to gold nanoparticles in rats’ liver and colon after single exposure
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Adewale Olusola B.
Cairncross Lynn
Xakaza Hlumisa
Wickens Nicolas
Anadozie Scholastica O.
Davids Hajierah
Roux Saartjie
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Abstract
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Peptides play important roles in the diagnosis, prognostic predictors, and treatment of various kinds of cancer. Peptides (p.C, p.L and p.14), derived from the phage display peptide libraries, specifically binds to colorectal cancer (CRC) cells in vitro. To allow tumor specificity and selectivity for in vivo diagnosis of CRC, biotinylated p.C, p.L and p.14 were conjugated to AuNPs (14 nm) via the biotin-streptavidin interaction. Male Wistar rats were intravenously injected with a single dose (100 μg/kg body weight) of AuNPs (citrate-AuNPs, PEG-AuNPs, p.C-PEG-, p.L-PEG- and p.14-PEG-AuNPs). Animals were monitored for behavioral changes, and sacrificed either 14 days or 84 days post-injection. Biochemical changes, oxidative stress, and histology of the liver and colon were assessed. No significant changes were noted in the rats injected with all the AuNPs, except p.L-PEG-AuNPs that caused significant toxicity (p?
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KEYWORD
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Colorectal cancer, Diagnosis, Gold nanoparticles, Peptides, Polyethylene glycol
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